青春期补充益生菌改善LPS引起的小鼠免疫反应和行为问题
创作:Mona 审核:mildbreeze 2019年07月16日
  • 用脂多糖(LPS)处理青春期小鼠,可导致成年后持久的抑郁样(雌性)和焦虑样(雄性)行为、增加雄性小鼠的应激反应和应激诱导的下丘脑室旁核TLR4的表达;
  • 同时补充益生菌(含4种乳杆菌的开菲尔培养物)能改善青春期LPS处理引起的小鼠短期和长期异常,且雌雄有别;
  • 包括减少疾病行为和体重减轻,预防外周和中枢神经系统的细胞因子增加及肠道菌群改变,阻断应激诱导的雄性小鼠下丘脑旁核室中TLR4表达的增加。
主编推荐语
mildbreeze
青春期是身体和大脑关键的发育期,肠道菌群在这一时期的作用尚缺乏研究。《Brain Behavior and Immunity》近期发表的一项研究显示,给小鼠在青春期补充益生菌,或能通过改变肠道菌群组成、减少急性炎症反应、阻断应激诱导的大脑内TLR4表达增加,来防止青春期LPS暴露引起的小鼠行为异常,且该作用具有性别特异性。
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Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner

青春期摄入益生菌可以减轻脂多糖引起的免疫反应,并以性别特异性的方式防止成年后应激性抑郁和焦虑类行为

10.1016/j.bbi.2019.06.016

2019-06-15, Article

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Puberty/adolescence is a significant period of development and a time with a high emergence of psychiatric disorders. During this period, there is increased neuroplasticity and heightened vulnerability to stress and inflammation. The gut microbiome regulates stress and inflammatory responses and can alter brain chemistry and behaviour. However, the role of the gut microbiota during pubertal development remains largely uninvestigated. The current study examined gut manipulation with probiotics during puberty in CD1 mice on lipopolysaccharide (LPS)-induced immune responses and enduring effects on anxiety- and depression-like behaviours and stress-reactivity in adulthood. Probiotics reduced LPS-induced sickness behaviour at 12 h in females and at 48 h following LPS treatment in males. Probiotics also reduced LPS-induced changes in body weight at 48 h post-treatment in females. Probiotic treatment also prevented LPS-induced increases in pro- and anti-inflammatory peripheral cytokines at 8 h following LPS treatment, reduced central cytokine mRNA expression in the hypothalamus, hippocampus and PFC, and prevented LPS-induced changes to in the gut microbiota. A single exposure to LPS during puberty resulted in enduring depression-like behaviour in female mice, and anxiety-like behaviour in male mice in adulthood. However, pubertal exposure to probiotics prevented enduring LPS-induced depression-like behaviour in females and anxiety-like behaviors in males. Moreover, probiotics altered toll-like receptor-4 activity in the paraventricular nucleus of the hypothalamus (PVN) in males in response to a novel stressor in adulthood. Our results suggest that the gut microbiome plays an important role in pubertal neurodevelopment. These findings indicate that exposure to probiotics during puberty mitigates inflammation and decreases stress-induced vulnerabilities to emotional behaviours later in life, in a sex-specific manner.

First Authors:
Emma Murray

Correspondence Authors:
Nafissa Ismail

All Authors:
Emma Murray,Rupali Sharma,Kevin B Smith,Kendall D Mar,Rudra Barve,Matthew Lukasik,Atiqa F Pirwani,Etienne Malette-Guyon,Sanjeevani Lamba,Bronwen J Thomas,Homa Sadeghi-Emamchaie,Jacky Liang,Jean-François Mallet,Chantal Matar,Nafissa Ismail

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