婴儿肠道菌群与母乳成份相关
创作:Epi汪 审核:Epi汪 2019年05月18日
  • 纳入121名KOALA出生队列中健康、母乳喂养、一个月大的婴儿,收集粪便及母乳;
  • 婴儿粪便菌群与性别、分娩方式、母乳寡糖(HMOs)有关,特别是与乳酰、岩藻糖(基)乳糖有关;
  • 婴儿粪便菌群可聚类为三类菌型:A,多样化;B,双歧杆菌主导;C,双歧杆菌和拟杆菌属共同主导;
  • 不同菌型对HMOs的降解能力不同;
  • 部分菌属相对丰度增高与HMOs降解存在正相关,如双歧杆菌、拟杆菌属及乳酸杆菌属。
  • 母乳中HMOs是影响婴儿肠道菌群的重要因素。
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Epi汪
发表在《Molecular Nutrition and Food Research》上的研究为母乳成份与婴儿肠道菌群的关联进一步提供证据。母乳中的人乳寡糖成份一直是研究的热点。本研究将婴儿肠道菌群根据菌型特征分为3个类型,并揭示了不同的菌型与母乳中人乳寡糖的关联。
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Correlating Infant Faecal Microbiota Composition and Human Milk Oligosaccharide Consumption by Microbiota of One-Month Old Breastfed Infants

一个月大母乳喂养的婴儿粪便菌群结构与人乳寡糖成分的关联

10.1002/mnfr.201801214

2019-04-24, Article

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SCOPE: Understanding biological functions of different free human milk oligosaccharides (HMOs) in shaping gastrointestinal tract microbiota during infancy is of great interest. We examined a link between HMOs in maternal milk and infant faecal microbiota composition and investigated the role of microbiota in degrading HMOs within the GI tract of healthy, breastfed, one-month old infants.
METHODS AND RESULTS: Maternal breast milk and corresponding infant faeces originated from the KOALA Birth Cohort. HMOs were quantified in milk and infant faecal samples using PGC-UPLC-MS and HPAEC-PAD. Faecal microbiota composition was characterised using Illumina HiSeq amplicon 16S rRNA sequencing. The composition associated with gender, mode of delivery, and milk HMOs: Lacto-N-fucopentaose I and 2'-Fucosyllactose. Overall, Bifidobacterium, Bacteroides, Escherichia-Shigella and Parabacteroides were predominating genera. We detected three different patterns in the infant faecal microbiota structure. Gastrointestinal degradation of HMOs was strongly associated with faecal microbiota composition, and there was a link between utilisation of specific HMOs and abundance of various phylotypes (OTUs).
CONCLUSIONS: HMOs in maternal milk are among important factors shaping GI tract microbiota composition in one-month old breastfed infants. Infant's ability to metabolise different HMOs strongly correlate with faecal microbiota composition, and with phylotypes within genera Bifidobacterium, Bacteroides and Lactobacillus. This article is protected by copyright. All rights reserved.

First Authors:
Klaudyna Borewicz,Hauke Smidt

Correspondence Authors:
Klaudyna Borewicz

All Authors:
Klaudyna Borewicz,Fangjie Gu,Edoardo Saccenti,Ilja C W Arts,John Penders,Carel Thijs,Sander S van Leeuwen,Cordula Lindner,Arjen Nauta,Ellen van Leusen,Henk A Schols,Hauke Smidt

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