Cell子刊:少吃甲硫氨酸延长早衰小鼠寿命
创作:FU 审核:周旸 2018年09月05日
  • 甲硫氨酸限制(MR)型饮食可延长两种不同的早衰模型小鼠的寿命;
  • 在早衰小鼠体内,MR改变了炎症和DNA损伤应答相关信号通路的异常转录;
  • 在野生型和早衰小鼠体内,MR改善脂质谱、修复脂质和胆汁酸失调,改变了胆汁酸水平及其分子缀合方式;
  • 富含胆汁酸的饮食可改善早衰小鼠健康并延长其寿命;
  • 体内可能存在与MR延长寿命相关的代谢途径,说明有可能通过饮食干预治疗早衰。
主编推荐语
周旸
甲硫氨酸限制(MR)可缓解小鼠的衰老相关疾病并延长寿命。本文通过阐释MR对早衰小鼠转录组和代谢组的影响,发现MR可改变衰老相关炎症和DNA损伤应答的异常,并改善脂质谱,可改善早衰小鼠的健康状态并延长寿命,对研究MR的促健康机制、开发饮食干预手段具有参考价值。
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Cell Reports [IF:8.109]

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

甲硫氨酸限制延长早衰小鼠的寿命、改变脂质和胆汁酸代谢

10.1016/j.celrep.2018.07.089

2018-08-28, Article

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Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan. Methionine restriction (MR) delays the appearance of age-related diseases and increases longevity in normal mice. However, the effect of MR on premature aging remains to be elucidated. Here, we describe that MR extends lifespan in two different mouse models of Hutchinson-Gilford progeria syndrome (HGPS) by reversing the transcriptome alterations in inflammation and DNA-damage response genes present in this condition. Further, MR improves the lipid profile and changes bile acid levels and conjugation, both in wild-type and in progeroid mice. Notably, treatment with cholic acid improves the health span and lifespan in vivo. These results suggest the existence of a metabolic pathway involved in the longevity extension achieved by MR and support the possibility of dietary interventions for treating progeria.

First Authors:
Clea Bárcena

Correspondence Authors:
José M P Freije,Carlos López-Otín

All Authors:
Clea Bárcena,Pedro M Quirós,Sylvère Durand,Pablo Mayoral,Francisco Rodríguez,Xurde M Caravia,Guillermo Mariño,Cecilia Garabaya,María Teresa Fernández-García,Guido Kroemer,José M P Freije,Carlos López-Otín

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