Science重磅综述:肠道菌群链起饮食和健康(一图读懂)
  • MAC(菌群可用碳水化合物)、脂肪、蛋白、微量营养素和食品添加剂深入影响肠道菌群和人体健康;
  • 生酮、古式、素食、地中海、限定碳水化合物饮食及发酵食品或对特定人群有益,但亟需结合菌群进行深入研究;
  • 饮食干预商业化在加速,但大量基础性问题未解决,且大部分理论基础源自动物模型;
  • 菌群可塑性很强,但这是双刃剑,不恰当干预方法或适得其反;
  • 未来需明确对饮食快速响应的关键微生物,并结合多组学、新算法等建立个体化干预方案。
#一张图读懂系列文献#
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蓝灿辉 | 热心肠先生
2018年11月16日上线的Science杂志,以封面形式推出了“饮食和健康”专辑,发表了4篇重量级综述。其中关于肠道菌群的文章,系统性阐述了不同的饮食成分对肠道菌群、代谢产物的深入影响,进而阐述了相关进程对人体细胞、代谢、生理功能以及慢性疾病发生的至关重要作用,也对未来需要解决的问题提出了展望。文章内容非常扎实,三张图举例说明了目前被了解得最深入的菌群相关代谢过程。这篇综述是开放下载的,值得专业人士逐字逐句认真阅读,我们也特别将图改造成了一图读懂,希望能帮助读者了解核心内容。强烈推荐!
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Science [IF:41.845]

The gut microbiota at the intersection of diet and human health

在饮食和人体健康交汇之处的肠道菌群

10.1126/science.aau5812

2018-11-16, Review

Abstract & Authors:展开

Abstract:收起
Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease. Dietary nutrients are essential not only for human health but also for the health and survival of the trillions of microbes that reside within the human intestines. Diet is a key component of the relationship between humans and their microbial residents; gut microbes use ingested nutrients for fundamental biological processes, and the metabolic outputs of those processes may have important impacts on human physiology. Studies in humans and animal models are beginning to unravel the underpinnings of this relationship, and increasing evidence suggests that it may underlie some of the broader effects of diet on human health and disease.

First Authors:
Christopher L Gentile

Correspondence Authors:
Tiffany L Weir

All Authors:
Christopher L Gentile,Tiffany L Weir

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