肠道微生物组与肿瘤免疫治疗
秦楠
时长:19:29 分会场:2019中国肠道大会 - 消化道肿瘤大会
肠道是人体内最大的淋巴器官,存在超过70%的T细胞,是绝大多数记忆T细胞的居住地。肠道微生物组可以通过直接物理接触、代谢产物以及肠道粘膜结构成分改变等多种机制与宿主免疫系统相互作用。近年来,越来越多的证据表明肠道微生物在肿瘤免疫治疗中发挥着至关重要的作用。在临床前模型中,通过调节肠道微生物组可以改善宿主对癌症治疗的反应,并且已验证微生物组在黑色素瘤、非小细胞肺癌、肾细胞癌和尿路上皮癌等多种癌症的免疫治疗中的效用。然而,之前的研究对癌症患者中微生物组的动态变化关注较少,仍然缺乏对微生物组如何有助于提高肿瘤免疫治疗效果的系统性认识。因此,今后还需更多的基础及临床研究,以深入剖析微生物组与肿瘤免疫治疗疗效的关联。
秦楠
同济大学附属第十人民医院
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