在过去的一年多时间里，全球肠道领域研究继续高歌猛进，取得了颇多令人瞩目的进展。
2023肠道大会来临之际，我们基于《热心肠日报》中收录的2022年5月以来一年期间（2022年5月1日至2023年4月30日）发表的肠道相关领域论文，进行了多维度评选，形成了《热心肠日报》2022-2023年度榜单。
2022年度榜单参评的文章共有3388篇，发表在420个不同的期刊上，累计影响因子达到了82902.36，平均影响因子24.48。其中来自Cell、Nature、Science的文章133篇，来自NEJM、Lancet、JAMA的文章54篇。
本榜单仅代表热心肠研究院基于自身数据所做的优选，可能存在主观因素干扰等不足，仅供参考。欢迎在文末留言提出批评、建议和意见。
本篇发布“全球肠道菌群研究五大机构”。
提示：下述文章点击中文标题可直达热心肠日报，点击英文标题可访问论文官网。
哈佛大学
2022年5月以来代表性论文（部分）
Nature. 2022 Jun;606(7915):754-760. doi: 10.1038/s41586-022-04648-7
Discovery of bioactive microbial gene products in inflammatory bowel disease
science. 2022 Jun 3;376(6597):eabm1483. doi: 10.1126/science.abm1483.
High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome
Nature. 2022 Sep;609(7927):582-589. doi: 10.1038/s41586-022-05181-3.
Akkermansia muciniphila phospholipid induces homeostatic immune responses
Nature. 2022 Sep;609(7927):582-589. doi: 10.1038/s41586-022-05181-3.
Identification of trypsin-degrading commensals in the large intestine
Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024.
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning
Cell. 2022 Dec 22;185(26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023.
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
Cell. 2023 Feb 16;186(4):877-891.e14. doi: 10.1016/j.cell.2023.01.002.
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states
Nature子刊：肠道菌群代谢5-ASA，降低其对炎症性肠病的疗效
Nat Med. 2023 Mar;29(3):700-709. doi: 10.1038/s41591-023-02217-7.
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
康奈尔大学
2022年5月以来代表性论文（部分）
Nature. 2022 Oct;610(7933):752-760. doi: 10.1038/s41586-022-05309-5.
Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota
Nature. 2022 Oct;610(7933):744-751. doi: 10.1038/s41586-022-05141-x.
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Cell. 2022 Sep 29;185(20):3807-3822.e12. doi: 10.1016/j.cell.2022.09.015.
A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors
Cell. 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008.
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Nature. 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y.
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation
耶鲁大学
2022年5月以来代表性论文（部分）
Nature. 2022 Jul;607(7919):563-570. doi: 10.1038/s41586-022-04949-x.
Within-host evolution of a gut pathobiont facilitates liver translocation
Cell. 2022 Nov 23;185(24):4526-4540.e18. doi: 10.1016/j.cell.2022.10.008.
A microbial transporter of the dietary antioxidant ergothioneine
Science. 2023 Mar 17;379(6637):1149-1156. doi: 10.1126/science.abn7229.
Bacteria require phase separation for fitness in the mammalian gut
Science. 2022 Oct 28;378(6618):eabm3233. doi: 10.1126/science.abm3233.
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cell Host Microbe. 2022 Jul 13;30(7):988-1002.e6. doi: 10.1016/j.chom.2022.05.004.
Interspecies commensal interactions have nonlinear impacts on host immunity
加州大学系统
2022年5月以来代表性论文（部分）
Cell. 2022 Sep 15;185(19):3467-3486.e16. doi: 10.1016/j.cell.2022.08.021.
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
Cell. 2022 Sep 29;185(20):3789-3806.e17. doi: 10.1016/j.cell.2022.09.005.
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
Cell. 2022 Aug 18;185(17):3263-3277.e15. doi: 10.1016/j.cell.2022.06.050.
Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes
Cell. 2023 Jan 5;186(1):17-31. doi: 10.1016/j.cell.2022.11.017.
Phage therapy: From biological mechanisms to future directions
Science. 2022 Jul;377(6601):eabp9960. doi: 10.1126/science.abp9960.
The microbiome and gut homeostasis
斯坦福大学
2022年5月以来代表性论文（部分）
Cell. 2022 Sep 15;185(19):3617-3636.e19. doi: 10.1016/j.cell.2022.08.003.
Design, construction, and in vivo augmentation of a complex gut microbiome
Science. 2023 Apr 14;380(6641):203-210. doi: 10.1126/science.abp9563.
Engineered skin bacteria induce antitumor T cell responses against melanoma
Science. 2022 Jun 10;376(6598):1220-1223. doi: 10.1126/science.abj2972.
Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Nat Biotechnol. 2023 Apr 27. doi: 10.1038/s41587-023-01754-3.
Quantifying bias introduced by sample collection in relative and absolute microbiome measurements
Nature子刊：gutSMASH助力评估肠道菌群特定代谢潜力
Nat Biotechnol. 2023 Feb 13. doi: 10.1038/s41587-023-01675-1.
gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota
